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Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

The receptor tyrosine kinase, erythropoietin-producing hepatocellular A4 (EphA4), was recently identified as a molecular target for Alzheimer’s disease (AD). We found that blockade of the interaction of the receptor and its ligands, ephrins, alleviates the disease phenotype in an AD transgenic mouse...

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Detalles Bibliográficos
Autores principales:	Gu, Shuo, Fu, Wing-Yu, Fu, Amy K. Y., Tong, Estella Pui Sze, Ip, Fanny C. F., Huang, Xuhui, Ip, Nancy Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943255/ https://www.ncbi.nlm.nih.gov/pubmed/29743517 http://dx.doi.org/10.1038/s41598-018-25790-1

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