Relevance of arginine residues in Cu(II)-induced DNA breakage and Proteinase K resistance of H1 histones

This work analyzes the involvement of arginines in copper/H(2)O(2)-induced DNA breakage. Copper is a highly redox active metal which has been demonstrated to form compounds with arginines. For this aim we used mixtures of pGEM3 DNA plasmid and two types of H1 histones which differ only in their argi...

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Detalles Bibliográficos
Autores principales: Piscopo, Marina, Trifuoggi, Marco, Scarano, Carmela, Gori, Carla, Giarra, Antonella, Febbraio, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943286/
https://www.ncbi.nlm.nih.gov/pubmed/29743544
http://dx.doi.org/10.1038/s41598-018-25784-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943286/
https://www.ncbi.nlm.nih.gov/pubmed/29743544
http://dx.doi.org/10.1038/s41598-018-25784-z

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