Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems. [Image: see text]

Detalles Bibliográficos
Autores principales: Italiano, Antoine, Touati, Nathan, Litière, Saskia, Collin, Françoise, Pourquier, Philippe, Gronchi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943428/
https://www.ncbi.nlm.nih.gov/pubmed/29656586
http://dx.doi.org/10.1002/cam4.1403
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author Italiano, Antoine
Touati, Nathan
Litière, Saskia
Collin, Françoise
Pourquier, Philippe
Gronchi, Alessandro
author_facet Italiano, Antoine
Touati, Nathan
Litière, Saskia
Collin, Françoise
Pourquier, Philippe
Gronchi, Alessandro
author_sort Italiano, Antoine
collection PubMed
description We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems. [Image: see text]
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spelling pubmed-59434282018-05-14 Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial Italiano, Antoine Touati, Nathan Litière, Saskia Collin, Françoise Pourquier, Philippe Gronchi, Alessandro Cancer Med Clinical Cancer Research We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems. [Image: see text] John Wiley and Sons Inc. 2018-04-15 /pmc/articles/PMC5943428/ /pubmed/29656586 http://dx.doi.org/10.1002/cam4.1403 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Italiano, Antoine
Touati, Nathan
Litière, Saskia
Collin, Françoise
Pourquier, Philippe
Gronchi, Alessandro
Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title_full Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title_fullStr Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title_full_unstemmed Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title_short Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
title_sort prospective assessment of the predictive value of the brca1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the eortc 62091 trial
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943428/
https://www.ncbi.nlm.nih.gov/pubmed/29656586
http://dx.doi.org/10.1002/cam4.1403
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