Substrate specificity of human MCPIP1 endoribonuclease

MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded RNAs. Our studies revealed cleavage sites pre...

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Detalles Bibliográficos
Autores principales: Wilamowski, Mateusz, Gorecki, Andrzej, Dziedzicka-Wasylewska, Marta, Jura, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943514/
https://www.ncbi.nlm.nih.gov/pubmed/29743536
http://dx.doi.org/10.1038/s41598-018-25765-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943514/
https://www.ncbi.nlm.nih.gov/pubmed/29743536
http://dx.doi.org/10.1038/s41598-018-25765-2

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