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Substrate specificity of human MCPIP1 endoribonuclease
MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded RNAs. Our studies revealed cleavage sites pre...
Autores principales: | Wilamowski, Mateusz, Gorecki, Andrzej, Dziedzicka-Wasylewska, Marta, Jura, Jolanta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943514/ https://www.ncbi.nlm.nih.gov/pubmed/29743536 http://dx.doi.org/10.1038/s41598-018-25765-2 |
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