The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition

Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. Protein kinase CK2 is an evolutionary-conserved eukaryotic s...

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Detalles Bibliográficos
Autores principales: Ruiz-Carrillo, David, Lin, Jianqing, El Sahili, Abbas, Wei, Meng, Sze, Siu Kwan, Cheung, Peter C. F., Doerig, Christian, Lescar, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943518/
https://www.ncbi.nlm.nih.gov/pubmed/29743645
http://dx.doi.org/10.1038/s41598-018-25738-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943518/
https://www.ncbi.nlm.nih.gov/pubmed/29743645
http://dx.doi.org/10.1038/s41598-018-25738-5

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