Cargando…

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition

Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. Protein kinase CK2 is an evolutionary-conserved eukaryotic s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruiz-Carrillo, David, Lin, Jianqing, El Sahili, Abbas, Wei, Meng, Sze, Siu Kwan, Cheung, Peter C. F., Doerig, Christian, Lescar, Julien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943518/ https://www.ncbi.nlm.nih.gov/pubmed/29743645 http://dx.doi.org/10.1038/s41598-018-25738-5

Ejemplares similares

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
por: Dastidar, Eeshita G, et al.
Publicado: (2012)

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1
por: Dorin-Semblat, Dominique, et al.
Publicado: (2015)

Identification of tyrosine kinase inhibitors that halt Plasmodium falciparum parasitemia
por: Kesely, Kristina, et al.
Publicado: (2020)

Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote
por: Ward, Pauline, et al.
Publicado: (2004)

The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
por: Hitz, Eva, et al.
Publicado: (2021)

Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation
por: Graciotti, Michele, et al.
Publicado: (2014)

Copper Modulates the Catalytic Activity of Protein Kinase CK2
por: Chojnowski, John E., et al.
Publicado: (2022)

Dengue Virus Non-Structural Protein 5
por: El Sahili, Abbas, et al.
Publicado: (2017)

Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia
por: Kesely, Kristina R., et al.
Publicado: (2016)

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation
por: Reininger, Luc, et al.
Publicado: (2012)

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites
por: Rached, Fathia Ben, et al.
Publicado: (2012)

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony
por: Reininger, Luc, et al.
Publicado: (2011)

Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
por: Adderley, Jack, et al.
Publicado: (2022)

Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases
por: Morahan, Belinda J., et al.
Publicado: (2020)

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase
por: Mitcheson, Deborah F., et al.
Publicado: (2016)

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle
por: Dorin-Semblat, Dominique, et al.
Publicado: (2011)

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodiumfalciparum
por: Abdi, Abdirahman, et al.
Publicado: (2010)

The protein-phosphatome of the human malaria parasite Plasmodium falciparum
por: Wilkes, Jonathan M, et al.
Publicado: (2008)

Overexpression of Nuclear Protein Kinase CK2 α Catalytic Subunit (CK2α) as a Poor Prognosticator in Human Colorectal Cancer
por: Lin, Kai-Yuan, et al.
Publicado: (2011)

Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission
por: Kern, Selina, et al.
Publicado: (2014)

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces
por: Huang, Hao
Publicado: (2018)

Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum
por: Sah, Raj Kumar, et al.
Publicado: (2021)

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

Erythrocyte phospho-signalling is dynamically altered during infection with Plasmodium falciparum
por: Adderley, Jack D., et al.
Publicado: (2020)

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum
por: Swift, Russell P, et al.
Publicado: (2020)

Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits
por: Iyer, Uthra Balasubramaniyan, et al.
Publicado: (2022)

Protein Kinase CK2 in Cancer Energetics
por: Silva-Pavez, Eduardo, et al.
Publicado: (2020)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
por: Zhong, Wenhe, et al.
Publicado: (2017)

Spheroacanthocytes secondary to novel tyrosine kinase inhibitors
por: Ashby, Michael, et al.
Publicado: (2020)

Synthesis of Novel Halogenated Heterocycles Based on o-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2
por: Winiewska-Szajewska, Maria, et al.
Publicado: (2021)

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2
por: Spinello, Zaira, et al.
Publicado: (2021)

The Link between Protein Kinase CK2 and Atypical Kinase Rio1
por: Kubiński, Konrad, et al.
Publicado: (2017)

Screening a protein kinase inhibitor library against Plasmodium falciparum
por: Hallyburton, Irene, et al.
Publicado: (2017)

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes
por: Wilde, Mary-Louise, et al.
Publicado: (2019)

Association of the receptor for activated C-kinase 1 with ribosomes in Plasmodium falciparum
por: Erath, Jessey, et al.
Publicado: (2022)

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation
por: Fennell, Clare, et al.
Publicado: (2009)

On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation
por: Chua, Niying, et al.
Publicado: (2023)

Catalytic Specificity of Human Protein Tyrosine Kinases Revealed by Peptide Substrate Profiling
por: Blouin, Julie, et al.
Publicado: (2011)

Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase
por: Sun, Gongqin, et al.
Publicado: (2023)

Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
por: Nocka, Laura M, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_751773rvp95keovm7emalaqii9