Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

p53 mediates the DNA damage response (DDR) by regulating the expression of genes implicated in cell cycle arrest, senescence, programmed cell death (PCD), and metabolism. Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivat...

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Detalles Bibliográficos
Autores principales: Xu, Ruijuan, Garcia-Barros, Monica, Wen, Sally, Li, Fang, Lin, Chih-Li, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943524/
https://www.ncbi.nlm.nih.gov/pubmed/29229990
http://dx.doi.org/10.1038/s41418-017-0018-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943524/
https://www.ncbi.nlm.nih.gov/pubmed/29229990
http://dx.doi.org/10.1038/s41418-017-0018-y

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