Cargando…

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer

BACKGROUND: Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role of the E3 ligase WSB-1 in breast cancer biology in the context of the hypoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poujade, Flore-Anne, Mannion, Aarren, Brittain, Nicholas, Theodosi, Andrew, Beeby, Ellie, Leszczynska, Katarzyna B., Hammond, Ester M., Greenman, John, Cawthorne, Christopher, Pires, Isabel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943535/ https://www.ncbi.nlm.nih.gov/pubmed/29540773 http://dx.doi.org/10.1038/s41416-018-0056-3

Ejemplares similares

WSB1: from homeostasis to hypoxia
por: Haque, Moinul, et al.
Publicado: (2016)

WSB1 Involvement in Prostate Cancer Progression
por: Boldrini, Laura, et al.
Publicado: (2023)

The WSB1 Gene Is Involved in Pancreatic Cancer Progression
por: Archange, Cendrine, et al.
Publicado: (2008)

Altered Pancreatic Growth and Insulin Secretion in WSB/EiJ Mice
por: Ho, Maggie M., et al.
Publicado: (2014)

WSB1 promotes tumor metastasis by inducing pVHL degradation
por: Kim, Jung Jin, et al.
Publicado: (2015)

Nuclear mechanosensing of the aortic endothelium in health and disease
por: Mannion, Aarren J., et al.
Publicado: (2023)

WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides
por: Carneiro, Valdirene Leão, et al.
Publicado: (2021)

miR-28-5p inhibits the migration of breast cancer by regulating WSB2
por: Ma, Liang, et al.
Publicado: (2020)

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
por: Gao, Xiaomeng, et al.
Publicado: (2022)

Identification of Potential WSB1 Inhibitors by AlphaFold Modeling, Virtual Screening, and Molecular Dynamics Simulation Studies
por: Weng, Ye, et al.
Publicado: (2022)

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
por: Nucifora, Frederick C., et al.
Publicado: (2016)

miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth
por: Jia, Yan-Yan, et al.
Publicado: (2016)

Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10
por: Yang, Rui, et al.
Publicado: (2022)

Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice
por: Terrien, Jérémy, et al.
Publicado: (2019)

Tumour cell CD99 regulates transendothelial migration via CDC42 and actin remodelling
por: Mannion, Aarren J., et al.
Publicado: (2021)

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
por: Skwarska, Anna, et al.
Publicado: (2017)

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
por: Chen, Meng-Chuan, et al.
Publicado: (2017)

WSB2 as a target of Hedgehog signaling promoted the malignant biological behavior of Xuanwei lung cancer through regulating Wnt/β-catenin signaling
por: Wei, Xueqiang, et al.
Publicado: (2020)

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
por: Steele, Lynette, et al.
Publicado: (2021)

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition
por: Mannion, Aarren J., et al.
Publicado: (2023)

In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negative
por: Carvalho, M João, et al.
Publicado: (2010)

KDM4A regulates HIF-1 levels through H3K9me3
por: Dobrynin, Grzegorz, et al.
Publicado: (2017)

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality
por: Jiang, Yanyan, et al.
Publicado: (2016)

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer
por: Yau, Christina, et al.
Publicado: (2010)

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation
por: Leszczynska, Katarzyna B., et al.
Publicado: (2023)

An assessment of the effects of hormones on short term organ cultures of human breast carcinomata.
por: Beeby, D. I., et al.
Publicado: (1975)

Current Landscape of Targeted Therapies for Hormone-Receptor Positive, HER2 Negative Metastatic Breast Cancer
por: Ballinger, Tarah J., et al.
Publicado: (2018)

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1
por: Leszczynska, Katarzyna B., et al.
Publicado: (2016)

An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk
por: Yau, Christina, et al.
Publicado: (2013)

MON-476 Growth Hormone and the Glomerular Podocyte: Studies of Podocyte-Specific Growth Hormone Receptor Gene Deletion in Mice
por: Brittain, Alison, et al.
Publicado: (2019)

High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways
por: Åkerborg, Örjan, et al.
Publicado: (2019)

Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer
por: Leszczynska, Katarzyna B., et al.
Publicado: (2016)

Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2−negative endocrine-refractory metastatic breast cancer
por: Shah, Ami N, et al.
Publicado: (2020)

A scoping review comparing two common surgical approaches to the hip for hemiarthroplasty
por: Fullam, James, et al.
Publicado: (2019)

Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve
por: Maleki, Shohreh, et al.
Publicado: (2019)

SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?
por: Freiholtz, David, et al.
Publicado: (2023)

SAT406 Evaluation Of The Emotional And Cognitive Effects Of Hormone Therapy In Transgender Men And Women
por: Yaish, Iris, et al.
Publicado: (2023)

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
por: Foskolou, Iosifina P., et al.
Publicado: (2017)

Cornual heterotopic pregnancy: a case report
por: Poujade, Olivier, et al.
Publicado: (2009)

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism
por: Bowler, Elizabeth, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_njrbp0qip0iivdp0fhj90l1fmn