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Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes

Somatic cells acquire stem cell-like properties during cancerous transformation; however, mechanisms through which committed cells develop stemness and malignancy remain largely unknown. Here we uncovered upregulated stem cell program in leukaemic lymphoblasts of patients with IKZF1 alterations by a...

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Detalles Bibliográficos
Autores principales: Li, Zhen, Li, Shui-Ping, Li, Ruo-Yan, Zhu, Hua, Liu, Xia, Guo, Xiao-Lin, Mu, Li-Li, Cai, Jie-Jing, Bai, Fan, Chen, Guo-Qiang, Hong, Deng-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943605/
https://www.ncbi.nlm.nih.gov/pubmed/29743561
http://dx.doi.org/10.1038/s41419-018-0600-3