Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and pot...

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Autores principales: Su, Jung-Chen, Huang, Yu-Ting, Chen, Chang-Shi, Chiu, Hao-Chieh, Shiau, Chung-Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943958/
https://www.ncbi.nlm.nih.gov/pubmed/29271946
http://dx.doi.org/10.3390/molecules23010027
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author Su, Jung-Chen
Huang, Yu-Ting
Chen, Chang-Shi
Chiu, Hao-Chieh
Shiau, Chung-Wai
author_facet Su, Jung-Chen
Huang, Yu-Ting
Chen, Chang-Shi
Chiu, Hao-Chieh
Shiau, Chung-Wai
author_sort Su, Jung-Chen
collection PubMed
description Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.
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spelling pubmed-59439582018-11-13 Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus Su, Jung-Chen Huang, Yu-Ting Chen, Chang-Shi Chiu, Hao-Chieh Shiau, Chung-Wai Molecules Article Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created. MDPI 2017-12-22 /pmc/articles/PMC5943958/ /pubmed/29271946 http://dx.doi.org/10.3390/molecules23010027 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Jung-Chen
Huang, Yu-Ting
Chen, Chang-Shi
Chiu, Hao-Chieh
Shiau, Chung-Wai
Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title_full Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title_fullStr Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title_full_unstemmed Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title_short Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus
title_sort design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943958/
https://www.ncbi.nlm.nih.gov/pubmed/29271946
http://dx.doi.org/10.3390/molecules23010027
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