Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII

Selective inhibition of tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) isoforms IX and XII is a crucial prerequisite to develop successful anticancer therapeutics. Herein, we confirmed the efficacy of the 3-nitrobenzoic acid substructure in the design of potent and selective carboxylic acid de...

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Detalles Bibliográficos
Autores principales: Cau, Ylenia, Vullo, Daniela, Mori, Mattia, Dreassi, Elena, Supuran, Claudiu T., Botta, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943959/
https://www.ncbi.nlm.nih.gov/pubmed/29271882
http://dx.doi.org/10.3390/molecules23010017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943959/
https://www.ncbi.nlm.nih.gov/pubmed/29271882
http://dx.doi.org/10.3390/molecules23010017

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