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Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

BACKGROUND: Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in cynomol...

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Detalles Bibliográficos
Autores principales: Lindström, Erik, Rizoska, Biljana, Henderson, Ian, Terelius, Ylva, Jerling, Markus, Edenius, Charlotte, Grabowska, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944028/
https://www.ncbi.nlm.nih.gov/pubmed/29743078
http://dx.doi.org/10.1186/s12967-018-1497-4