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Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711
BACKGROUND: Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in cynomol...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944028/ https://www.ncbi.nlm.nih.gov/pubmed/29743078 http://dx.doi.org/10.1186/s12967-018-1497-4 |