RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

BACKGROUND: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AMP (cGAMP...

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Detalles Bibliográficos
Autores principales: Liu, Zhao-Shan, Zhang, Zi-Yu, Cai, Hong, Zhao, Ming, Mao, Jie, Dai, Jiang, Xia, Tian, Zhang, Xue-Min, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944131/
https://www.ncbi.nlm.nih.gov/pubmed/29760876
http://dx.doi.org/10.1186/s13578-018-0233-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944131/
https://www.ncbi.nlm.nih.gov/pubmed/29760876
http://dx.doi.org/10.1186/s13578-018-0233-3

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