Cargando…

Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Zi’ang, Chen, Yilei, Song, Lijiang, Yik, Jasper H. N., Haudenschild, Dominik R., Fan, Shunwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944179/ https://www.ncbi.nlm.nih.gov/pubmed/29773986 http://dx.doi.org/10.3389/fphar.2018.00174

Ejemplares similares

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
por: Yuan, Yu, et al.
Publicado: (2020)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro
por: Wang, Chuandong, et al.
Publicado: (2017)

CircSLC7A2 protects against osteoarthritis through inhibition of the miR‐4498/TIMP3 axis
por: Ni, Weiyu, et al.
Publicado: (2021)

Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis in Vivo and Inhibits RANKL-Induced Osteoclast Differentiation in Vitro
por: Wang, Qi, et al.
Publicado: (2018)

Inhibitory Effect of Cudratrixanthone U on RANKL-Induced Osteoclast Differentiation and Function in Macrophages and BMM Cells
por: Kim, Eun-Nam, et al.
Publicado: (2020)

Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption
por: Niu, Chenguang, et al.
Publicado: (2017)

Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer
por: Hassan, Md Sazzad, et al.
Publicado: (2021)

Corrigendum: Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis In Vivo and Inhibits RANKL-Induced Osteoclast Differentiation In Vitro
por: Wang, Qi, et al.
Publicado: (2020)

Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
por: Wang, Jing, et al.
Publicado: (2019)

Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice
por: Chen, Yongjie, et al.
Publicado: (2022)

Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway
por: Ni, Weiyu, et al.
Publicado: (2020)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
por: Zhou, Lin, et al.
Publicado: (2020)

Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
por: Xiong, Jinhu, et al.
Publicado: (2018)

RO4929097 regulates RANKL-induced osteoclast formation and LPS-mediated bone resorption
por: Huang, Tao, et al.
Publicado: (2021)

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
por: Wu, Zuoxing, et al.
Publicado: (2022)

Aminooxyacetic acid hemihydrochloride inhibits osteoclast differentiation and bone resorption by attenuating oxidative phosphorylation
por: Yang, Biao, et al.
Publicado: (2022)

Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption
por: Lim, Soomin, et al.
Publicado: (2023)

Serum amyloid A inhibits RANKL-induced osteoclast formation
por: Oh, Eunseo, et al.
Publicado: (2015)

The effects of vasoactive intestinal peptide on RANKL-induced osteoclast formation
por: Qu, Hongyi, et al.
Publicado: (2021)

Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice
por: Ai, Zexin, et al.
Publicado: (2020)

Water extract of Uncaria sinensis suppresses RANKL-induced bone loss by attenuating osteoclast differentiation and bone resorption
por: Ha, Hyunil, et al.
Publicado: (2017)

Dihydromyricetin Protects against Bone Loss in Ovariectomized Mice by Suppressing Osteoclast Activity
por: Zhao, Libo, et al.
Publicado: (2017)

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
por: Xiong, Jinhu, et al.
Publicado: (2015)

Magnesium Lithospermate B Protects against Lipopolysaccharide-Induced Bone Loss by Inhibiting RANKL/RANK Pathway
por: Wang, Jihai, et al.
Publicado: (2018)

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption
por: Liu, Xuqiang, et al.
Publicado: (2017)

Effects of Sparganii Rhizoma on Osteoclast Formation and Osteoblast Differentiation and on an OVX-Induced Bone Loss Model
por: Lee, Sungyub, et al.
Publicado: (2022)

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
por: Kim, Kabsun, et al.
Publicado: (2015)

Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1
por: Hou, Huanhuan, et al.
Publicado: (2020)

Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo
por: Xu, Qiang, et al.
Publicado: (2021)

Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis
por: Li, Chang-hong, et al.
Publicado: (2021)

An investigation and validation of CT scan in detection of spinal epidural adipose tissue
por: Chen, Yilei, et al.
Publicado: (2020)

Pristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways
por: Li, Xuedong, et al.
Publicado: (2021)

CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes
por: Liang, Yi, et al.
Publicado: (2023)

Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation
por: Jang, Seon-A, et al.
Publicado: (2021)

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways
por: Li, Jing, et al.
Publicado: (2022)

Potent interaction of flavopiridol with MRP1
por: Hooijberg, J H, et al.
Publicado: (1999)

Effect of P-glycoprotein on flavopiridol sensitivity
por: Boerner, S A, et al.
Publicado: (2001)

The Pharmacological Implications of Flavopiridol: An Updated Overview
por: Joshi, Hemant, et al.
Publicado: (2023)

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption
por: Jang, Jin Sun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hmggdik0aub71ql8urh67rnfck