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Competition between Li(+) and Na(+) in sodium transporters and receptors: Which Na(+)-Binding sites are “therapeutic” Li(+) targets?

Sodium (Na(+)) acts as an indispensable allosteric regulator of the activities of biologically important neurotransmitter transporters and G-protein coupled receptors (GPCRs), which comprise well-known drug targets for psychiatric disorders and addictive behavior. How selective these allosteric Na(+...

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Detalles Bibliográficos
Autores principales: Dudev, Todor, Mazmanian, Karine, Lim, Carmay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944251/
https://www.ncbi.nlm.nih.gov/pubmed/29780538
http://dx.doi.org/10.1039/c7sc05284g