A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis

Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an anthraquinone, both of polyketide origin. Sequencing of the dynemicin biosynthetic gene cluster in Micromonospora chersina previously identified an enediyne polyketide synth...

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Detalles Bibliográficos
Autores principales: Cohen, Douglas R., Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944350/
https://www.ncbi.nlm.nih.gov/pubmed/29359752
http://dx.doi.org/10.1038/nchem.2876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944350/
https://www.ncbi.nlm.nih.gov/pubmed/29359752
http://dx.doi.org/10.1038/nchem.2876

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