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A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an anthraquinone, both of polyketide origin. Sequencing of the dynemicin biosynthetic gene cluster in Micromonospora chersina previously identified an enediyne polyketide synth...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944350/ https://www.ncbi.nlm.nih.gov/pubmed/29359752 http://dx.doi.org/10.1038/nchem.2876 |