Cargando…

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

A series of triple action Pt(iv) prodrugs was designed to test the hypothesis that multi-action compounds, where each bioactive moiety intervenes in several cellular processes, might be more effective than a single agent at killing cancer cells. In particular, “triple action” Pt(iv) derivatives of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Petruzzella, Emanuele, Sirota, Roman, Solazzo, Irene, Gandin, Valentina, Gibson, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944384/
https://www.ncbi.nlm.nih.gov/pubmed/29780561
http://dx.doi.org/10.1039/c8sc00428e