NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review

INTRODUCTION: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many clinical studies. However, leukopenia, the most common toxicity, still restricts its clinical applications. Recent studies found that NUDT15 R139C polymorphism is strongly ass...

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Detalles Bibliográficos
Autores principales: Fei, Xiang, Shu, Qing, Hua, Bing-zhu, Wang, Shi-ying, Chen, Zhi-yong, Ge, Wei-hong, Fang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944482/
https://www.ncbi.nlm.nih.gov/pubmed/29702976
http://dx.doi.org/10.1097/MD.0000000000010301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944482/
https://www.ncbi.nlm.nih.gov/pubmed/29702976
http://dx.doi.org/10.1097/MD.0000000000010301

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