Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

BACKGROUND: The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expre...

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Detalles Bibliográficos
Autores principales: Chappell, Grace A., Israel, Jennifer W., Simon, Jeremy M., Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G., Bodnar, Wanda, Lieb, Jason D., Crawford, Gregory E., Rusyn, Ivan, Furey, Terrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944832/
https://www.ncbi.nlm.nih.gov/pubmed/29038090
http://dx.doi.org/10.1289/EHP1937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944832/
https://www.ncbi.nlm.nih.gov/pubmed/29038090
http://dx.doi.org/10.1289/EHP1937

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