Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Poly(ADP ribose) polymerase inhibitors (PARPi) target cancer cells deficient in homology-directed repair of DNA double-strand breaks (DSBs). In preclinical models, PARPi resistance is tied to altered nucleolytic processing (resection) at the 5’ ends of a DSB. For example, loss of either 53BP1 or Rev...

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Detalles Bibliográficos
Autores principales: Leland, Bryan A, Chen, Angela C, Zhao, Amy Y, Wharton, Robert C, King, Megan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945276/
https://www.ncbi.nlm.nih.gov/pubmed/29697047
http://dx.doi.org/10.7554/eLife.33402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945276/
https://www.ncbi.nlm.nih.gov/pubmed/29697047
http://dx.doi.org/10.7554/eLife.33402

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