Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism. Mechanistically, mutant p53 interacts with NRF2, increases its nuclear presence and r...

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Detalles Bibliográficos
Autores principales: Lisek, Kamil, Campaner, Elena, Ciani, Yari, Walerych, Dawid, Del Sal, Giannino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945496/
https://www.ncbi.nlm.nih.gov/pubmed/29755668
http://dx.doi.org/10.18632/oncotarget.24974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945496/
https://www.ncbi.nlm.nih.gov/pubmed/29755668
http://dx.doi.org/10.18632/oncotarget.24974

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