Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines

Mutation-driven activation of KRAS is crucial to cancer development. The human gene yields four mRNA splicing isoforms, 4A and 4B being translated to protein. Their different properties and oncogenic potential have been studied, but the mechanisms deciding the ratio 4A/4B are not known. To address t...

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Detalles Bibliográficos
Autores principales: Riffo-Campos, Ángela L., Gimeno-Valiente, Francisco, Rodríguez, Fernanda M., Cervantes, Andrés, López-Rodas, Gerardo, Franco, Luis, Castillo, Josefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945503/
https://www.ncbi.nlm.nih.gov/pubmed/29755673
http://dx.doi.org/10.18632/oncotarget.25016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945503/
https://www.ncbi.nlm.nih.gov/pubmed/29755673
http://dx.doi.org/10.18632/oncotarget.25016

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