MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

The MYC oncogenes and p53 have opposing yet interrelated roles in normal development and tumorigenesis. How MYCN expression alters the biology and clinical responsiveness of pediatric neuroblastoma remains poorly defined. Neuroblastoma is p53 wild type at diagnosis and repression of p53 signaling is...

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Detalles Bibliográficos
Autores principales: Agarwal, Saurabh, Milazzo, Giorgio, Rajapakshe, Kimal, Bernardi, Ronald, Chen, Zaowen, Barberi, Eveline, Koster, Jan, Perini, Giovanni, Coarfa, Cristian, Shohet, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945521/
https://www.ncbi.nlm.nih.gov/pubmed/29755654
http://dx.doi.org/10.18632/oncotarget.24859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945521/
https://www.ncbi.nlm.nih.gov/pubmed/29755654
http://dx.doi.org/10.18632/oncotarget.24859

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