RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells

The retinoid X receptor alpha (RXRα) is an important therapeutic target impacting diverse biological processes. Activation of RXRα is known to suppress cancer cell growth. However, the cellular mechanism has been elusive. In the present study, we addressed its role during stem cell differentiation a...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Li, Hui, Zhang, Shuangshuang, Zhang, Yujie, Wang, Nan, Zhou, Hao, He, Hongpeng, Hu, Guang, Zhang, Tong-Cun, Ma, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945609/
https://www.ncbi.nlm.nih.gov/pubmed/29748541
http://dx.doi.org/10.1038/s41419-018-0610-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945609/
https://www.ncbi.nlm.nih.gov/pubmed/29748541
http://dx.doi.org/10.1038/s41419-018-0610-1

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