Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

In this paper, we report our investigations on analogues of the anti-human immunodeficiency virus type 1 (HIV-1) integrase (IN) aptamer T30175 in which the individual thymidines forming the loops were replaced by 5-hydroxymethyl-2′-deoxyuridine residues (H). Circular dichroism, nuclear magnetic reso...

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Detalles Bibliográficos
Autores principales: Virgilio, Antonella, Amato, Teresa, Petraccone, Luigi, Esposito, Francesca, Grandi, Nicole, Tramontano, Enzo, Romero, Raquel, Haider, Shozeb, Gomez-Monterrey, Isabel, Novellino, Ettore, Mayol, Luciano, Esposito, Veronica, Galeone, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945619/
https://www.ncbi.nlm.nih.gov/pubmed/29749406
http://dx.doi.org/10.1038/s41598-018-25720-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945619/
https://www.ncbi.nlm.nih.gov/pubmed/29749406
http://dx.doi.org/10.1038/s41598-018-25720-1

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