TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we show that TGF-β transcriptionally induces MIR100HG lncRNA, containing miR-100, m...

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Detalles Bibliográficos
Autores principales: Ottaviani, Silvia, Stebbing, Justin, Frampton, Adam E., Zagorac, Sladjana, Krell, Jonathan, de Giorgio, Alexander, Trabulo, Sara M., Nguyen, Van T. M., Magnani, Luca, Feng, Hugang, Giovannetti, Elisa, Funel, Niccola, Gress, Thomas M., Jiao, Long R., Lombardo, Ylenia, Lemoine, Nicholas R., Heeschen, Christopher, Castellano, Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945639/
https://www.ncbi.nlm.nih.gov/pubmed/29748571
http://dx.doi.org/10.1038/s41467-018-03962-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945639/
https://www.ncbi.nlm.nih.gov/pubmed/29748571
http://dx.doi.org/10.1038/s41467-018-03962-x

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