SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons

Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested to exert effects opposite those of SIRT1; howeve...

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Detalles Bibliográficos
Autores principales: Romeo-Guitart, David, Leiva-Rodríguez, Tatiana, Espinosa-Alcantud, María, Sima, Núria, Vaquero, Alejandro, Domínguez- Martín, Helena, Ruano, Diego, Casas, Caty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945655/
https://www.ncbi.nlm.nih.gov/pubmed/29748539
http://dx.doi.org/10.1038/s41419-018-0553-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945655/
https://www.ncbi.nlm.nih.gov/pubmed/29748539
http://dx.doi.org/10.1038/s41419-018-0553-6

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