Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses

Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context of different IAV subtypes in mice. Here, we demonstrate that, as with the previously assessed...

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Detalles Bibliográficos
Autores principales: Alymova, Irina V., McCullers, Jonathan A., Kamal, Ram P., Vogel, Peter, Green, Amanda M., Gansebom, Shane, York, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945659/
https://www.ncbi.nlm.nih.gov/pubmed/29749408
http://dx.doi.org/10.1038/s41598-018-25707-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945659/
https://www.ncbi.nlm.nih.gov/pubmed/29749408
http://dx.doi.org/10.1038/s41598-018-25707-y

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