USP49 participates in the DNA damage response by forming a positive feedback loop with p53

The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on...

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Detalles Bibliográficos
Autores principales: Tu, Rongfu, Kang, Wenqian, Yang, Xuefei, Zhang, Qi, Xie, Xiaoyu, Liu, Wenbin, Zhang, Jinxiang, Zhang, Xiao-Dong, Wang, Hui, Du, Run-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945681/
https://www.ncbi.nlm.nih.gov/pubmed/29748582
http://dx.doi.org/10.1038/s41419-018-0475-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945681/
https://www.ncbi.nlm.nih.gov/pubmed/29748582
http://dx.doi.org/10.1038/s41419-018-0475-3

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