Cargando…

USP49 participates in the DNA damage response by forming a positive feedback loop with p53

The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tu, Rongfu, Kang, Wenqian, Yang, Xuefei, Zhang, Qi, Xie, Xiaoyu, Liu, Wenbin, Zhang, Jinxiang, Zhang, Xiao-Dong, Wang, Hui, Du, Run-Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945681/ https://www.ncbi.nlm.nih.gov/pubmed/29748582 http://dx.doi.org/10.1038/s41419-018-0475-3

Ejemplares similares

A negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10
por: Luo, Zhenghua, et al.
Publicado: (2019)

miR‐210 Participates in Hepatic Ischemia Reperfusion Injury by Forming a Negative Feedback Loop With SMAD4
por: Pan, Wen‐Ming, et al.
Publicado: (2020)

The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer
por: Huang, Ji, et al.
Publicado: (2022)

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
por: Campos-Iglesias, Diana, et al.
Publicado: (2023)

A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance
por: Zhang, Li‐Zhen, et al.
Publicado: (2020)

PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke-Induced COPD by Integrative Bioinformatics Analysis
por: Zhang, Qiang, et al.
Publicado: (2020)

The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity
por: Pant, Vinod, et al.
Publicado: (2013)

Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells
por: Hu, Yaling, et al.
Publicado: (2022)

Cholestasis Due to USP53 Deficiency
por: Bull, Laura N., et al.
Publicado: (2021)

Stress-specific response of the p53-Mdm2 feedback loop
por: Hunziker, Alexander, et al.
Publicado: (2010)

The long non‐coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49
por: Qian, Xinye, et al.
Publicado: (2020)

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
por: Ye, Liya, et al.
Publicado: (2019)

Transcriptional Feedback Loops in the Caprine Circadian Clock System
por: Gao, Dengke, et al.
Publicado: (2022)

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation
por: Wu, Linhui, et al.
Publicado: (2022)

USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
por: Pan, Ting, et al.
Publicado: (2019)

Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data
por: Kang, Ye, et al.
Publicado: (2023)

Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc
por: Bian, Erbao, et al.
Publicado: (2021)

mdm-miR828 Participates in the Feedback Loop to Regulate Anthocyanin Accumulation in Apple Peel
por: Zhang, Bo, et al.
Publicado: (2020)

Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity
por: Pant, Vinod, et al.
Publicado: (2014)

MOZ Forms an Autoregulatory Feedback Loop with miR-223 in AML and Monocyte/Macrophage Development
por: Jiang, Ming, et al.
Publicado: (2018)

Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop
por: Chakraborty, Riddhita, et al.
Publicado: (2015)

DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2
por: Zeng, Cheng, et al.
Publicado: (2022)

Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins
por: Meng, Lingjiao, et al.
Publicado: (2018)

The cotton MYB108 forms a positive feedback regulation loop with CML11 and participates in the defense response against Verticillium dahliae infection
por: Cheng, Huan-Qing, et al.
Publicado: (2016)

Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress
por: Yang, H, et al.
Publicado: (2015)

USP11 controls R-loops by regulating senataxin proteostasis
por: Jurga, Mateusz, et al.
Publicado: (2021)

USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-κBp65
por: Zhou, Lili, et al.
Publicado: (2018)

FBW7-Aurora B-p53 feedback loop regulates mitosis and cell growth
por: Wang, Yifan, et al.
Publicado: (2012)

Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells
por: Morita, Ken, et al.
Publicado: (2017)

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
por: Khoronenkova, Svetlana V., et al.
Publicado: (2012)

CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4
por: Qi, Mei, et al.
Publicado: (2019)

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop
por: Zhang, Y, et al.
Publicado: (2015)

CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
por: Wang, Hui, et al.
Publicado: (2020)

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability
por: Ma, Zhi-Qiang, et al.
Publicado: (2022)

p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop
por: Leslie, Patrick L., et al.
Publicado: (2018)

P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration
por: Gong, Junhua, et al.
Publicado: (2023)

MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response
por: Issler, Maria Vitória C., et al.
Publicado: (2017)

The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
por: Gu, Weigang, et al.
Publicado: (2022)

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
por: Wu, Min, et al.
Publicado: (2016)

p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability
por: Chiang, Cheng-Ming
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k28nhp68smq8cvv6f434o8iine