Cargando…

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

Oncogenic signals lead to premature senescence in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. Oncogene‐induced senescence (OIS) prevents aberrant cell division and tumor initiation. In order to identify new regulators of OIS, we per...

Descripción completa

Detalles Bibliográficos
Autores principales:	Warnier, Marine, Flaman, Jean‐Michel, Chouabe, Christophe, Wiel, Clotilde, Gras, Baptiste, Griveau, Audrey, Blanc, Elena, Foy, Jean‐Philippe, Mathot, Pauline, Saintigny, Pierre, Van Coppenolle, Fabien, Vindrieux, David, Martin, Nadine, Bernard, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946064/ https://www.ncbi.nlm.nih.gov/pubmed/29446526 http://dx.doi.org/10.1111/acel.12736

Ejemplares similares

Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca(2+) Levels in Senescent Cells
por: Raynard, Clotilde, et al.
Publicado: (2022)

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes
por: Griveau, Audrey, et al.
Publicado: (2018)

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
por: Collin, Guillaume, et al.
Publicado: (2018)

Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
por: Ziegler, Dorian V., et al.
Publicado: (2021)

Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy
por: Jaber, Sara, et al.
Publicado: (2023)

Loss of Pla2r1 decreases cellular senescence and age‐related alterations caused by aging and Western diets
por: Massemin, Amélie, et al.
Publicado: (2023)

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
por: Le Calvé, Benjamin, et al.
Publicado: (2016)

NF‐κB‐dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells
por: Raynard, Clotilde, et al.
Publicado: (2022)

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program
por: Ferrand, Mylène, et al.
Publicado: (2015)

mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a
por: Chen, Ajuan, et al.
Publicado: (2022)

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging
por: Huna, Anda, et al.
Publicado: (2021)

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
por: Griveau, Audrey, et al.
Publicado: (2020)

Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts
por: Vindrieux, David, et al.
Publicado: (2013)

A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice
por: Aiba, Isamu, et al.
Publicado: (2023)

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling
por: Ma, Xingjie, et al.
Publicado: (2018)

Correction: mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence through regulating the sodium channel Scn1a
por: Chen, Ajuan, et al.
Publicado: (2023)

Transport and senescence
por: Bernard, David, et al.
Publicado: (2015)

Depolarization by an RF field
por: Buon, Jean
Publicado: (1989)

Polarization and controlled depolarization
por: Koutchouk, Jean-Pierre
Publicado: (1993)

Depolarizing system for LEP
por: Buon, Jean, et al.
Publicado: (1987)

TRPV1 Channels Are New Players in the Reticulum–Mitochondria Ca(2+) Coupling in a Rat Cardiomyoblast Cell Line
por: Tessier, Nolwenn, et al.
Publicado: (2023)

Depolarization enhancement due to the energy spread
por: Buon, Jean
Publicado: (1988)

Skin Tumors Rb(eing) Uncovered
por: Costa, Clotilde, et al.
Publicado: (2013)

RSK3 switches cell fate: from stress-induced senescence to malignant progression
por: Huna, Anda, et al.
Publicado: (2023)

Influence of Generated Defects by Ar Implantation on the Thermoelectric Properties of ScN
por: Burcea, Razvan, et al.
Publicado: (2022)

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients
por: Foy, Jean-Philippe, et al.
Publicado: (2020)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Correction to Influence of Generated Defects by Ar Implantation on the Thermoelectric Properties of ScN
por: Burcea, Razvan, et al.
Publicado: (2023)

Evidence of depolarization and ellipticity of high harmonics driven by ultrashort bichromatic circularly polarized fields
por: Barreau, Lou, et al.
Publicado: (2018)

Depolarization of electrons
por: Robinson, K W
Publicado: (1967)

Sec61 complex/translocon: The role of an atypical ER Ca(2+)-leak channel in health and disease
por: Parys, Jan B., et al.
Publicado: (2022)

Identification of a Gene-Expression-Based Surrogate of Genomic Instability during Oral Carcinogenesis
por: Truchard, Eléonore, et al.
Publicado: (2022)

To Rb or not to Rb
por: Wells, William A.
Publicado: (2002)

Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68
por: Yaung, Stephanie J., et al.
Publicado: (2015)

Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome
por: Nakajima, Tadashi, et al.
Publicado: (2021)

La mundialización de la cultura /
por: Warnier, Jean-Pierre
Publicado: (2002)

Program modification /
por: Warnier, Jean Dominique
Publicado: (1978)

A Radiomics Approach to Identify Immunologically Active Tumor in Patients with Head and Neck Squamous Cell Carcinomas
por: Nguyen, Tan Mai, et al.
Publicado: (2023)

SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families
por: Wijeyeratne, Yanushi D., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k49hcq6c6himr7pljkofgpatf1