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Distinct chromatin signatures of DNA hypomethylation in aging and cancer

Cancer is an aging‐associated disease, but the underlying molecular links between these processes are still largely unknown. Gene promoters that become hypermethylated in aging and cancer share a common chromatin signature in ES cells. In addition, there is also global DNA hypomethylation in both pr...

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Detalles Bibliográficos
Autores principales: Pérez, Raúl F., Tejedor, Juan Ramón, Bayón, Gustavo F., Fernández, Agustín F., Fraga, Mario F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946083/
https://www.ncbi.nlm.nih.gov/pubmed/29504244
http://dx.doi.org/10.1111/acel.12744