Effect of the S‐nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma

RATIONALE: Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. OBJECTIVES: An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects of GSNOR inhibition. Mechanistic studies aime...

Descripción completa

Detalles Bibliográficos
Autores principales: Que, Loretta G., Yang, Zhonghui, Lugogo, Njira L., Katial, Rohit K., Shoemaker, Steven A., Troha, Janice M., Rodman, David M., Tighe, Robert M., Kraft, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946144/
https://www.ncbi.nlm.nih.gov/pubmed/29642282
http://dx.doi.org/10.1002/iid3.220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946144/
https://www.ncbi.nlm.nih.gov/pubmed/29642282
http://dx.doi.org/10.1002/iid3.220

Ejemplares similares