Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

INTRODUCTION: T cell and NK cell cytotoxicity can be mediated via the perforin/granzyme system and Fas Ligand (FasL, CD178). FasL is synthesized as a type II transmembrane protein that binds its cognate receptor Fas (CD95). Membrane‐bound FasL is expressed on the plasma membrane of activated lymphoc...

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Detalles Bibliográficos
Autores principales: Lee, Jeansun, Dieckmann, Nele M.G., Edgar, James R., Griffiths, Gillian M., Siegel, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946154/
https://www.ncbi.nlm.nih.gov/pubmed/29642281
http://dx.doi.org/10.1002/iid3.219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946154/
https://www.ncbi.nlm.nih.gov/pubmed/29642281
http://dx.doi.org/10.1002/iid3.219

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