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ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization

BACKGROUND: Anti-Silencing Factor 1 (ASF1) is a conserved H3–H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an important role in regulating the supply of H3.1/2 and H4 to the CAF-1 chromati...

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Detalles Bibliográficos
Autores principales: Horard, Béatrice, Sapey-Triomphe, Laure, Bonnefoy, Emilie, Loppin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946387/
https://www.ncbi.nlm.nih.gov/pubmed/29751847
http://dx.doi.org/10.1186/s13072-018-0189-x