Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal...

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Detalles Bibliográficos
Autores principales: Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946456/
https://www.ncbi.nlm.nih.gov/pubmed/29719251
http://dx.doi.org/10.1016/j.celrep.2018.03.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946456/
https://www.ncbi.nlm.nih.gov/pubmed/29719251
http://dx.doi.org/10.1016/j.celrep.2018.03.122

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