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Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier
Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal...
Autores principales: | Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946456/ https://www.ncbi.nlm.nih.gov/pubmed/29719251 http://dx.doi.org/10.1016/j.celrep.2018.03.122 |
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