Cargando…

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1‐linked amyotrophic lateral sclerosis mice

Cystatin C (CysC) is a major protein component of Bunina bodies, which are a pathological hallmark observed in the remaining motor neurons of patients with amyotrophic lateral sclerosis (ALS). Dominant mutations in the SOD1 gene, encoding Cu/Zn superoxide dismutase (SOD1), are causative for a subset...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Seiji, Komine, Okiru, Endo, Fumito, Wakasugi, Keisuke, Yamanaka, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947136/ https://www.ncbi.nlm.nih.gov/pubmed/29282717 http://dx.doi.org/10.1111/jnc.14285

Ejemplares similares

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
por: Watanabe, Seiji, et al.
Publicado: (2014)

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons
por: Lasiene, Jurate, et al.
Publicado: (2016)

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS
por: Watanabe, Seiji, et al.
Publicado: (2016)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis
por: Amporndanai, Kangsa, et al.
Publicado: (2020)

ALS-linked TDP-43(M337V) knock-in mice exhibit splicing deregulation without neurodegeneration
por: Watanabe, Seiji, et al.
Publicado: (2020)

Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype
por: Nizzardo, M., et al.
Publicado: (2016)

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease
por: Yamashita, Hirofumi, et al.
Publicado: (2023)

Corrigendum: Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease
por: Yamashita, Hirofumi, et al.
Publicado: (2023)

SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization
por: Banci, Lucia, et al.
Publicado: (2008)

Metal-deficient SOD1 in amyotrophic lateral sclerosis
por: Hilton, James B., et al.
Publicado: (2015)

Cystatin C: A Candidate Biomarker for Amyotrophic Lateral Sclerosis
por: Wilson, Meghan E., et al.
Publicado: (2010)

Glial Cells in Amyotrophic Lateral Sclerosis
por: Lasiene, Jurate, et al.
Publicado: (2011)

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?
por: Saccon, Rachele A., et al.
Publicado: (2013)

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis
por: Paré, Bastien, et al.
Publicado: (2018)

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis
por: Tokuda, Eiichi, et al.
Publicado: (2017)

Neuroinflammation in motor neuron disease
por: Komine, Okiru, et al.
Publicado: (2015)

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway
por: Nishino, Kohei, et al.
Publicado: (2019)

Structural and Functional Analysis of Human SOD1 in Amyotrophic Lateral Sclerosis
por: Moreira, Lorenna Giannini Alves, et al.
Publicado: (2013)

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis
por: Tafuri, Francesco, et al.
Publicado: (2015)

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease
por: Pansarasa, Orietta, et al.
Publicado: (2018)

Intracerebroventricular delivery of vascular endothelial growth factor in patients with amyotrophic lateral sclerosis, a phase I study
por: Van Damme, Philip, et al.
Publicado: (2020)

FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis
por: Kabashi, Edor, et al.
Publicado: (2011)

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
por: Vehviläinen, Piia, et al.
Publicado: (2014)

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations
por: Jeon, Gye Sun, et al.
Publicado: (2018)

SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity
por: Berdyński, Mariusz, et al.
Publicado: (2022)

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
por: Sobue, Akira, et al.
Publicado: (2021)

Neuroinflammation in Alzheimer’s disease: microglial signature and their relevance to disease
por: Sobue, Akira, et al.
Publicado: (2023)

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice
por: Juranek, Judyta K., et al.
Publicado: (2016)

Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations
por: Tokuda, Eiichi, et al.
Publicado: (2016)

A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis
por: McAlary, L., et al.
Publicado: (2022)

Amyotrophic lateral sclerosis with SOD1 mutations shows distinct brain metabolic changes
por: Canosa, Antonio, et al.
Publicado: (2022)

Measurement of cystatin C functional activity in the cerebrospinal fluid of amyotrophic lateral sclerosis and control subjects
por: Wilson, Meghan E, et al.
Publicado: (2013)

Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis
por: Zhu, Yu, et al.
Publicado: (2018)

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Song, Lin, et al.
Publicado: (2014)

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
por: Beers, David R., et al.
Publicado: (2011)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes
por: Komine, Okiru, et al.
Publicado: (2018)

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells
por: Pokrishevsky, Edward, et al.
Publicado: (2017)

Accelerated Disease Onset with Stabilized Familial Amyotrophic Lateral Sclerosis (ALS)-linked Mutant TDP-43 Proteins
por: Watanabe, Shoji, et al.
Publicado: (2013)

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
por: Banerjee, Rebecca, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_bvrj5a6e0dnpo0priadn3htqt4