Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

The NLRP3 inflammasome is an important regulator of the sterile inflammatory response, and its activation by host‐derived sterile molecules leads to the intracellular activation of caspase‐1, processing of the pro‐inflammatory cytokines interleukin‐1β (IL‐1β)/IL‐18, and pyroptotic cell death. Inappr...

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Detalles Bibliográficos
Autores principales: Baldwin, Alex G., Tapia, Victor S., Swanton, Tessa, White, Claire S., Beswick, James A., Brough, David, Freeman, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947144/
https://www.ncbi.nlm.nih.gov/pubmed/29331080
http://dx.doi.org/10.1002/cmdc.201700731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947144/
https://www.ncbi.nlm.nih.gov/pubmed/29331080
http://dx.doi.org/10.1002/cmdc.201700731

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