Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours

A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision‐cut slices from Kras‐driven non‐small‐cell lung cancer with var...

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Detalles Bibliográficos
Autores principales: Närhi, Katja, Nagaraj, Ashwini S, Parri, Elina, Turkki, Riku, van Duijn, Petra W, Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I, Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M, Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947161/
https://www.ncbi.nlm.nih.gov/pubmed/29443392
http://dx.doi.org/10.1002/path.5059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947161/
https://www.ncbi.nlm.nih.gov/pubmed/29443392
http://dx.doi.org/10.1002/path.5059

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