Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids

The hapalindole-type alkaloids naturally show striking late stage diversification of what was believed to be a conserved intermediate, cis-indolyl vinyl isonitrile (1a). Here we demonstrate enzymatically, as well as through applying a synthetic biology approach, that the pathway generating 1a (itsel...

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Detalles Bibliográficos
Autores principales: Ittiamornkul, Kuljira, Zhu, Qin, Gkotsi, Danai S., Smith, Duncan R. M., Hillwig, Matthew L., Nightingale, Nicole, Goss, Rebecca J. M., Liu, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947517/
https://www.ncbi.nlm.nih.gov/pubmed/29861925
http://dx.doi.org/10.1039/c5sc02919h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947517/
https://www.ncbi.nlm.nih.gov/pubmed/29861925
http://dx.doi.org/10.1039/c5sc02919h

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