Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE

Molecular replacement (MR) is the predominant route to solution of the phase problem in macromolecular crystallography. Although routine in many cases, it becomes more effortful and often impossible when the available experimental structures typically used as search models are only distantly homolog...

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Detalles Bibliográficos
Autores principales: Rigden, Daniel J., Thomas, Jens M. H., Simkovic, Felix, Simpkin, Adam, Winn, Martyn D., Mayans, Olga, Keegan, Ronan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947759/
https://www.ncbi.nlm.nih.gov/pubmed/29533226
http://dx.doi.org/10.1107/S2059798318002310