Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

LeuT, a prokaryotic member of the neurotransmitter:sodium symporter (NSS) family, is an established structural model for mammalian NSS counterparts. We investigate the substrate translocation mechanism of LeuT by measuring the solution-phase structural dynamics of the transporter in distinct functio...

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Detalles Bibliográficos
Autores principales: Merkle, Patrick S., Gotfryd, Kamil, Cuendet, Michel A., Leth-Espensen, Katrine Z., Gether, Ulrik, Loland, Claus J., Rand, Kasper D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947982/
https://www.ncbi.nlm.nih.gov/pubmed/29756037
http://dx.doi.org/10.1126/sciadv.aar6179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947982/
https://www.ncbi.nlm.nih.gov/pubmed/29756037
http://dx.doi.org/10.1126/sciadv.aar6179

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