Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector

Efforts to develop drugs for Alzheimer’s disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells carrying the major genetic risk factor apolipoprote...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chengzhong, Najm, Ramsey, Xu, Qin, Jeong, Dah-eun, Walker, David, Balestra, Maureen E., Yoon, Seo Yeon, Yuan, Heidi, Li, Gang, Miller, Zachary A., Miller, Bruce L., Malloy, Mary J., Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948154/
https://www.ncbi.nlm.nih.gov/pubmed/29632371
http://dx.doi.org/10.1038/s41591-018-0004-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948154/
https://www.ncbi.nlm.nih.gov/pubmed/29632371
http://dx.doi.org/10.1038/s41591-018-0004-z

Ejemplares similares