Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector

Efforts to develop drugs for Alzheimer’s disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells carrying the major genetic risk factor apolipoprote...

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Detalles Bibliográficos
Autores principales: Wang, Chengzhong, Najm, Ramsey, Xu, Qin, Jeong, Dah-eun, Walker, David, Balestra, Maureen E., Yoon, Seo Yeon, Yuan, Heidi, Li, Gang, Miller, Zachary A., Miller, Bruce L., Malloy, Mary J., Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948154/
https://www.ncbi.nlm.nih.gov/pubmed/29632371
http://dx.doi.org/10.1038/s41591-018-0004-z

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