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LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients

Concentrations of cell-free DNA (cfDNA) circulating in blood and its epigenetic variation, such as DNA methylation, may provide useful diagnostic or prognostic information. Long interspersed nuclear element-1 (LINE-1) constitutes approximately 20% of the human genome and its 5’UTR region is CpG rich...

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Detalles Bibliográficos
Autores principales: Dunaeva, Marina, Derksen, Merel, Pruijn, Ger J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948235/
https://www.ncbi.nlm.nih.gov/pubmed/28707075
http://dx.doi.org/10.1007/s12035-017-0679-z