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The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9

The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal mode...

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Detalles Bibliográficos
Autores principales: Sánchez-Blázquez, Pilar, Pozo-Rodrigálvarez, Andrea, Merlos, Manuel, Garzón, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948242/
https://www.ncbi.nlm.nih.gov/pubmed/28779350
http://dx.doi.org/10.1007/s12035-017-0697-x